Saracens quartet Mako Vunipola, Chris Ashton, Brad Barritt and Alex Goode have all been named in England's 23-man squad for the crunch match against New Zealand on Saturday.
Mouritz Botha meanwhile was released from international duty and will be available for the Men in Black's match against Gloucester on Sunday.
Farrell is expected to start at fly-half in the absence of Toby Flood while Barritt and Goode are set to retain their places at centre and full back respectively.
England Head Coach Stuart Lancaster told the RFU: “Firstly to those guys who won’t be coming back in tomorrow - their attitude over the last five weeks has been first-rate with the energy and enthusiasm they have brought to the squad both on and off the field.
"Unfortunately we can only pick 23 but they have all pushed hard for selection and I know they will go back to their clubs hungry to force their way into the Elite Player Squad in January.
“For those in Saturday’s squad the message is clear - last week we went toe to toe with the second best team in the world and felt we should have won.
"Now we have a chance to take on the number one side in front of a passionate Twickenham crowd, who have been fantastic throughout the QBE Internationals, and it is a challenge we will meet head on.”
Kick off at Twickenham is at 2.30pm.
England squad in full
Alex Corbisiero (London Irish) Dan Cole (Leicester Tigers) James Haskell (London Wasps) Joe Launchbury (London Wasps) Courtney Lawes (Northampton Saints) Ben Morgan (Gloucester Rugby) David Paice (London Irish) Geoff Parling (Leicester Tigers) Chris Robshaw (Harlequins, capt) Mako Vunipola (Saracens) David Wilson (Bath Rugby) Tom Wood (Northampton Saints) Tom Youngs (Leicester Tigers)
Chris Ashton (Saracens) Brad Barritt (Saracens) Mike Brown (Harlequins) Freddie Burns (Gloucester Rugby) Danny Care (Harlequins) Owen Farrell (Saracens) Alex Goode (Saracens) Jonathan Joseph (London Irish) Manusamoa Tuilagi (Leicester Tigers) Ben Youngs (Leicester Tigers)
The following 11 players have been released back to their clubs:
Mouritz Botha (Saracens) Tom Biggs (Bath Rugby) Lee Dickson (Northampton Saints) Phil Dowson (Northampton Saints) Toby Flood (Leicester Tigers) Tom Johnson (Exeter Chiefs) Tom Palmer (London Wasps) Charlie Sharples (Gloucester Rugby) Jordan Turner-Hall (Harlequins) Thomas Waldrom (Leicester Tigers) Nick Wood (Gloucester Rugby)