Saracens' Maro Itoje has retained his place in Eddie Jones' starting England XV to face Wales in the Six Nations on Saturday and is one of four Sarries included.

The lock will win his third cap for the Red Rose after starting against Ireland and coming on against Italy.

He is joined in the side by Owen Farrell, again selected at outside centre with George Ford preferred at fly-half, Billy Vunipola and George Kruis.

On the bench there is a spot for Mako Vunipola.

However, Jamie George has been ruled out of the rest of the Six Nations with a bicep injury.

“It is a shame that Jamie George misses out through injury and we wish him well in his recovery, but it provides a great opportunity for Luke Cowan-Dickie to show what he’s about," explained Jones

The Red Rose go into the clash at Twickenham (4pm kick-off) leading the championship by a point over Warren Gatland's side after winning their first three fixtures.

England XV v Wales: 15. Mike Brown (Harlequins), 14. Anthony Watson (Bath Rugby), 13. Jonathan Joseph (Bath Rugby), 12. Owen Farrell (Saracens), 11. Jack Nowell (Exeter Chiefs), 10. George Ford (Bath Rugby), 9. Ben Youngs (Leicester Tigers); 8. Billy Vunipola (Saracens), 7. James Haskell (Wasps), 6. Chris Robshaw (Harlequins), 5. George Kruis (Saracens), 4. Maro Itoje (Saracens), 3. Dan Cole (Leicester Tigers), 2. Dylan Hartley (captain) (Northampton Saints), 1. Joe Marler (Harlequins).

Replacements: 16. Luke Cowan-Dickie (Exeter Chiefs), 17. Mako Vunipola (Saracens), 18. Kieran Brookes (Northampton Saints), 19. Joe Launchberry (Waps), 20. Jack Clifford (Harlequins), 21. Danny Care (Harlequins), 22. Man Tuilagi (Leicester Tigers), 23. Elliot Daly (Wasps).