Saracens' Owen Farrell will miss the entire of England's Six Nations campaign with a knee injury, it has been confirmed by the RFU.

The 23-year-old fly-half was injured during the first half of Sarries' 18-6 defeat at Clermont Auvergne in the European Champions Cup on Sunday.

It has since been confirmed Farrell will play no part in the Six Nations - due to begin next month - due to a 'high-grade' medial ligament strain.

England begin their Six Nations campaign away to France on Friday, February 6.