Saracens' George Kruis will make his first England start in their Six Nations opener against Wales on Friday, whilst Billy Vunipola also starts.

England head coach Stuart Lancaster has picked the pair alongside Richard Wigglesworth and Mako Vunipola, who are named as replacements.

Lancaster said of his decision: "We’ve had to make some tight calls but we are excited about the side selected for what will be a big challenge.

"Billy Vunipola has also been playing well for Saracens and it’s good to be able to give George Kruis his first international start after his impressive run off the bench in November."

Vunipola is in line to win his 13th cap for the Red Rose, whilst Kruis will earn his fifth after making his debut against New Zealand last year.

The game kicks off at 8.05pm in Cardiff on Friday.