Four Saracens players featured as England began their Six Nations campaign in ideal fashion, winning 21-16 against Wales in Cardiff on Friday night.

George Kruis and Billy Vunipola both started for Stuart Lancaster's injury-hit team, whilst Mako Vunipola and Richard Wigglesworth featured as replacements for the Red Rose, who came from ten points down to triumph.

Warren Gatland's side took the initiative early on and raced into a ten-point lead via the boot of Leigh Halfpenny and a converted Rhys Webb try.

Anthony Watson - one of five England players making their Six Nations bow - crossed for his maiden try before Halfpenny and George Ford traded penalties; Wales leading 13-8.

A long-range drop goal from Dan Biggar soon enhanced Wales' lead to eight points before half time.

After the break, Jonathan Joseph scored his first test try to reduce the deficit before England edged in front from a Ford penalty after Alex Cuthbert was sin binned.

Dave Attwood thought he had given England the win when he went over by the TMO ruled out the try due to obstruction from replacement Nick Easter.

The win was finally sealed when Ford dissected the points with another long-range penalty to get England's Six Nations campaign up-and-running in the best possible fashion.

England host Italy at Twickenham next Saturday.