Saracens hooker Jamie George has been ruled out of England's Six Nations clash against Wales at Twickenham on Saturday but five Sarries are included in the squad.

Eddie Jones' side top the standings after winning each of their three fixtures so far. They are a point ahead of Wales, in second, prior to Saturday's meeting (4pm kick-off).

A bicep injury means George, 25, will miss the game but Maro Itoje, George Kruis, Billy Vunipola, Mako Vunipola and Owen Farrell are included by the Red Rose.

"Jamie hurt his bicep in training," said England forwards coach and former Sarries skipper Steve Borthwick.

"He will be out for a period of time, eight to ten weeks has been suggested by the doctor."